Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251713 | 0.90 | ALDH1A1 (0.44) | ALDH1A1HCAR2LMNAKDM4EESR1 | |
| SCHEMBL13969444 | 0.86 | ALDH1A1 (0.37) | PPM1BPTPN1PPP1CCALDH1A1LMNA | |
| SCHEMBL14369814 | 0.83 | GPR84 (0.31) | GPR84 | |
| SCHEMBL2533154 | 0.81 | — | — | |
| SCHEMBL13947268 | 0.77 | NFKB1 (0.37) | MAPK1GPR84 | |
| SCHEMBL22042208 | 0.76 | GPR84 (0.34) | ALDH1A1TSHRMAPK1GPR84 | |
| SCHEMBL2118565 | 0.76 | GPR84 (0.34) | ALDH1A1TSHRMAPK1GPR84 | |
| SCHEMBL14394185 | 0.76 | GPR84 (0.34) | ALDH1A1TSHRMAPK1GPR84 | |
| SCHEMBL11422586 | 0.75 | GPR84 (0.36) | GPR84 | |
| SCHEMBL6325196 | 0.74 | PPM1B (0.40) | PPM1BPTPN1PPP1CCALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027127-A1 | Trans Pyrrolidinyl Derivates and Their Pharmaceutical Use | FAUST PHARMACEUTICALS (FR) | 2008-01-31 | — | — | US | disclosed |
| EP-1751099-A1 | CIS PYRROLIDINYL DERIVATIVES AND THEIR USES | Faust Pharmaceuticals (FR) | 2007-02-14 | — | — | EP | disclosed |
| EP-1751098-A1 | TRANS PYRROLIDINYL DERIVATIVES AND THEIR PHARMACEUTICAL USE | Faust Pharmaceuticals (FR) | 2007-02-14 | — | — | EP | disclosed |
| EP-1728511-A1 | New use of phenethicillin and salts thereof. | Faust Pharmaceuticals (FR) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005118533-A1 | TRANS PYRROLIDINYL DERIVATIVES AND THEIR PHARMACEUTICAL USE | FAUST PHARMACEUTICALS (FR) | 2005-12-15 | — | — | WO | disclosed |
| WO-2005118534-A1 | CIS PYRROLIDINYL DERIVATIVES AND THEIR USES | FAUST PHARMACEUTICALS (FR) | 2005-12-15 | — | — | WO | disclosed |
| EP-1604978-A1 | Trans pyrrolidinyl derivatives and their pharmaceutical uses | Faust Pharmaceuticals (FR) | 2005-12-14 | — | — | EP | disclosed |
| EP-1604977-A1 | CIS pyrrolidinyl derivatives and their uses | Faust Pharmaceuticals (FR) | 2005-12-14 | — | — | EP | disclosed |
| EP-0621865-B1 | RAPAMYCIN DERIVATIVE AND ITS MEDICINAL USE | SMITHKLINE BEECHAM PLC (GB) | 2003-04-02 | — | — | EP | disclosed |
| EP-0683783-B1 | RAPAMYCIN DERIVATIVE PROCESS FOR ITS PREPARATION AND ITS USE | SMITHKLINE BEECHAM PLC (GB) | 2001-07-11 | — | — | EP | disclosed |
| US-5583018-A | FUNGICIDE, IMMUNOMODULATOR | SMITHKLINE BEECHAM P.L.C. (GB) | 1996-12-10 | — | — | US | disclosed |
| EP-0711297-A1 | RAPAMYCIN DERIVATIVE WITH ANTIMICROBIAL, ANTICANCER AND IMMUNOMODULATION ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-05-15 | — | — | EP | disclosed |
| US-5491229-A | BACTERICIDES, FUNGICIDES, IMMUNOSUPPRESSANTS, IMMUNOMODULATORS | SMITHKLINE BEECHAM PLC (GB) | 1996-02-13 | — | — | US | disclosed |
| EP-0683783-A1 | RAPAMYCIN DERIVATIVE PROCESS FOR ITS PREPARATION AND ITS USE | SMITHKLINE BEECHAM PLC (GB) | 1995-11-29 | — | — | EP | disclosed |
| EP-0683784-A1 | 7,42-BIS (O-DEMETHYL) RAPAMYCIN | SMITHKLINE BEECHAM PLC (GB) | 1995-11-29 | — | — | EP | disclosed |
| WO-1995004060-A1 | RAPAMYCIN DERIVATIVE WITH ANTIMICROBIAL, ANTICANCER AND IMMUNOMODULATION ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-02-09 | — | — | WO | disclosed |
| EP-0621865-A1 | RAPAMYCIN DERIVATIVE AND ITS MEDICINAL USE | SMITHKLINE BEECHAM PLC (GB) | 1994-11-02 | — | — | EP | disclosed |
| WO-1994018206-A1 | RAPAMYCIN DERIVATIVE PROCESS FOR ITS PREPARATION AND ITS USE | SMITHKLINE BEECHAM P.L.C. (GB) | 1994-08-18 | — | — | WO | disclosed |
| WO-1994018208-A1 | 7,42-BIS (O-DEMETHYL) RAPAMYCIN | SMITHKLINE BEECHAM PLC (GB) | 1994-08-18 | — | — | WO | disclosed |
| WO-1993011130-A1 | RAPAMYCIN DERIVATIVE AND ITS MEDICINAL USE | SMITHKLINE BEECHAM PLC (GB) | 1993-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027127-A1 | Trans Pyrrolidinyl Derivates and Their Pharmaceutical Use | SUCNR1, GLRA1, CNR1 | PPM1B 1633/4885PTPN1 788/4885PPP1CC 2889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.