Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768018 | 0.83 | ALDH1A1 (0.43) | GAAALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL4777347 | 0.78 | NR1H4 (0.39) | GAAALDH1A1MAPTLMNACYP1A2 | |
| SCHEMBL4776590 | 0.78 | GAA (0.42) | GAAALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL4777561 | 0.77 | GAA (0.36) | GAAALDH1A1MAPTLMNACYP1A2 | |
| SCHEMBL4777314 | 0.77 | GAA (0.38) | GAAALDH1A1MAPTLMNACYP1A2 | |
| SCHEMBL4771365 | 0.76 | GAA (0.37) | GAAALDH1A1MAPTLMNACYP1A2 | |
| SCHEMBL5571819 | 0.76 | SLC6A4 (0.42) | GAAALDH1A1MAPTLMNACYP1A2 | |
| SCHEMBL4775060 | 0.75 | GAA (0.39) | GAAALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL4775247 | 0.74 | GAA (0.48) | GAAALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL4768047 | 0.74 | REN (0.41) | GAAALDH1A1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |