Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764829 | 0.91 | PIN1 (0.38) | L3MBTL1ALDH1A1LMNAPOLBPIN1 | |
| SCHEMBL4765186 | 0.87 | CCKAR (0.43) | L3MBTL1LMNAPOLBPIN1TSPO | |
| SCHEMBL4764817 | 0.87 | TSPO (0.38) | L3MBTL1KDM4EALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL4769985 | 0.83 | CA12 (0.41) | L3MBTL1ALDH1A1CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL4773796 | 0.82 | CTSA (0.39) | L3MBTL1MAPTCTSA | |
| SCHEMBL4771490 | 0.78 | CYP2C9 (0.40) | L3MBTL1KDM4EALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL4771777 | 0.78 | MME (0.42) | L3MBTL1KDM4EALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL4767426 | 0.75 | KMT2A (0.41) | L3MBTL1KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4768165 | 0.75 | CTSA (0.38) | CTSA | |
| SCHEMBL4767481 | 0.75 | PTK2 (0.49) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |