Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 2/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.38 |
| ▸ | CTSA | P10619 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGFR | P43088 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764829 | 0.89 | PIN1 (0.38) | TSPOPIN1POLBHTTNPSR1 | |
| SCHEMBL4771629 | 0.87 | L3MBTL1 (0.40) | TSPOPIN1POLBL3MBTL1CTSA | |
| SCHEMBL4769954 | 0.86 | TSPO (0.41) | CCKARTSPOCTSAKMT2ALMNA | |
| SCHEMBL4768165 | 0.85 | CTSA (0.38) | CTSASMN1; SMN2 | |
| SCHEMBL4775298 | 0.81 | ACHE (0.41) | POLBSMN1; SMN2KMT2ALMNA | |
| SCHEMBL4764854 | 0.80 | CCKAR (0.45) | CCKARPOLBL3MBTL1 | |
| SCHEMBL4767426 | 0.78 | KMT2A (0.41) | NPSR1L3MBTL1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL4773796 | 0.78 | CTSA (0.39) | L3MBTL1CTSA | |
| SCHEMBL4769975 | 0.77 | ATF1 (0.39) | CCKARPIN1 | |
| SCHEMBL4773748 | 0.76 | KMT2A (0.35) | FABP4FABP5SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |