Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4472381 | 0.79 | ALDH1A1 (0.48) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL2384632 | 0.79 | ALDH1A1 (0.45) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL2384633 | 0.79 | ALDH1A1 (0.45) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL10997019 | 0.75 | KMT2A (0.42) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL27390221 | 0.75 | KMT2A (0.42) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL17967376 | 0.70 | MAPT (0.43) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL17967374 | 0.70 | MAPT (0.43) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL10914144 | 0.70 | RAB9A (0.40) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL29921207 | 0.68 | ALDH1A1 (0.57) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7370339 | 0.68 | ALDH1A1 (0.57) | MAPK1CYP1A2CYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556382-B1 | 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2008-05-28 | — | — | EP | disclosed |
| EP-1556382-A1 | 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041817-A1 | 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2004-05-21 | — | — | WO | disclosed |