Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 6/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | IL2 | P60568 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210876 | 0.91 | DYRK1A (0.38) | L3MBTL1ESR1MCHR1PRSS12DYRK1A | |
| SCHEMBL5216211 | 0.90 | SMN1; SMN2 (0.39) | L3MBTL1ESR1MCHR1PRSS12DYRK1A | |
| SCHEMBL5214032 | 0.90 | SMN1; SMN2 (0.39) | L3MBTL1ESR1MCHR1PRSS12DYRK1A | |
| SCHEMBL5214045 | 0.89 | PDE4A (0.38) | L3MBTL1GAAESR1MCHR1NPBWR1 | |
| SCHEMBL5763779 | 0.88 | ALDH1A1 (0.37) | ESR1MCHR1NPBWR1PRSS12 | |
| SCHEMBL4762803 | 0.88 | NPC1 (0.38) | L3MBTL1ESR1MCHR1NPBWR1PRSS12 | |
| SCHEMBL5213831 | 0.88 | RXRA (0.35) | L3MBTL1ESR1MCHR1PRSS12DYRK1A | |
| SCHEMBL5252572 | 0.86 | QDPR (0.49) | L3MBTL1PRSS12PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL5214658 | 0.86 | PIK3CD (0.38) | L3MBTL1ESR1MCHR1NPBWR1PRSS12 | |
| SCHEMBL5254722 | 0.84 | PDE4B (0.41) | L3MBTL1PRSS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885356-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2008-02-13 | — | — | EP | claimed |
| WO-2006089106-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR INHIBITING LEUKOCYTE ACCUMULATION | ICOS CORPORATION (US) | 2006-08-24 | — | — | WO | claimed |