Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.90 |
| ▸ | LMNA | P02545 | 1/20 | 0.90 |
| ▸ | GAA | P10253 | 1/20 | 0.90 |
| ▸ | MAPT | P10636 | 1/20 | 0.90 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.90 |
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.68 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000216 | 0.99 | KDM4E (0.92) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL4765974 | 0.92 | MAPT (0.77) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL15823836 | 0.88 | GAA (0.74) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL1873507 | 0.86 | PKM (1.00) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL4769081 | 0.81 | SIGMAR1 (0.74) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL3387201 | 0.81 | SIGMAR1 (0.74) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL2500700 | 0.81 | KDM4E (0.65) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL4196782 | 0.81 | SIGMAR1 (0.73) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27491125 | 0.80 | KDM4E (0.59) | KDM4ELMNAGAAMAPTSMN1; SMN2 | |
| SCHEMBL13297961 | 0.80 | L3MBTL1 (0.83) | KDM4ELMNAGAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |