Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.73 |
| ▸ | HTR7 | P34969 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.57 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568486 | 0.98 | SIGMAR1 (0.72) | SIGMAR1HTR7MAPTKDM4ELMNA | |
| SCHEMBL5198457 | 0.89 | HTR7 (0.74) | SIGMAR1HTR7KDM4ELMNASMN1; SMN2 | |
| SCHEMBL4617661 | 0.89 | SFRP1 (0.61) | SIGMAR1HTR7MAPTKDM4ELMNA | |
| SCHEMBL17374138 | 0.86 | HTR7 (0.66) | SIGMAR1HTR7KDM4ELMNASMN1; SMN2 | |
| SCHEMBL29172771 | 0.84 | HTR7 (0.60) | SIGMAR1HTR7KDM4ELMNASMN1; SMN2 | |
| SCHEMBL3889428 | 0.84 | HTR7 (0.68) | SIGMAR1HTR7MAPTKDM4ELMNA | |
| SCHEMBL3719058 | 0.84 | PKM (0.69) | HTR7MEN1KMT2A | |
| SCHEMBL4769081 | 0.84 | SIGMAR1 (0.74) | SIGMAR1MAPTKDM4ELMNAGAA | |
| SCHEMBL3387201 | 0.84 | SIGMAR1 (0.74) | SIGMAR1MAPTKDM4ELMNAGAA | |
| SCHEMBL6291901 | 0.84 | SIGMAR1 (0.69) | SIGMAR1MAPTKDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009022171-A1 | PYRIDINYIIOXY PYRIDINES AS ALK5 INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | disclosed |