Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | PFKFB1 | P16118 | 2/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.36 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLI1 | P08151 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772053 | 1.00 | SCN4A (0.43) | SCN4AELANEPFKFB1PFKFB3PFKFB2 | |
| SCHEMBL4772327 | 0.83 | SCN4A (0.36) | SCN4AELANEPFKFB1PFKFB3PFKFB2 | |
| SCHEMBL4772136 | 0.80 | SCN4A (0.46) | SCN4AELANEPFKFB1PFKFB3PFKFB2 | |
| SCHEMBL4772142 | 0.80 | SCN4A (0.46) | SCN4AELANEPFKFB1PFKFB3PFKFB2 | |
| SCHEMBL6297408 | 0.73 | KDM4C (0.31) | ALDH1A1 | |
| SCHEMBL7017392 | 0.66 | SCN4A (0.46) | SCN4AELANEPFKFB1PFKFB3PFKFB2 | |
| SCHEMBL18580371 | 0.65 | SCN4A (0.65) | SCN4AELANEPFKFB1PFKFB3PFKFB2 | |
| SCHEMBL7302727 | 0.64 | SCN4A (0.53) | SCN4AKMT2A | |
| SCHEMBL490079 | 0.64 | GLI1 (0.66) | SCN4AGLI1KMT2ADPP4DPP8 | |
| SCHEMBL894617 | 0.64 | GLI1 (0.66) | SCN4AGLI1KMT2ADPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309565-B1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2008-04-09 | — | — | EP | claimed |
| US-6878704-B2 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-04-12 | — | — | US | claimed |
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-25 | — | — | US | claimed |
| EP-1309565-B1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2008-04-09 | — | — | EP | disclosed |
| US-6878704-B2 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-04-12 | — | — | US | disclosed |
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058937-A1 | Heterocyclic mutilin esters and their use as antibacterials | MLN, MSH2, MRPL21 | SCN4A 2891/4885ELANE 251/4885PFKFB1 2172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.