Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.51 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 2/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775955 | 1.00 | GCK (0.55) | GCKMRGPRX4PTGER1PTGER4PTGER2 | |
| SCHEMBL8406441 | 0.84 | GCK (0.57) | GCKMRGPRX4PTGER1PTGER4PTGER2 | |
| SCHEMBL9082648 | 0.82 | NR4A2 (0.54) | GCKMRGPRX4PTGER1NPC1HPGD | |
| SCHEMBL849174 | 0.79 | LMNA (0.48) | PTGER1PTGER4PTGER2PTGER3NPC1 | |
| SCHEMBL849175 | 0.79 | LMNA (0.48) | PTGER1PTGER4PTGER2PTGER3NPC1 | |
| SCHEMBL29556736 | 0.77 | MRGPRX4 (0.62) | MRGPRX4PTGER1NPC1HPGDRAB9A | |
| SCHEMBL1600077 | 0.77 | MRGPRX4 (0.62) | MRGPRX4PTGER1NPC1HPGDRAB9A | |
| SCHEMBL4280782 | 0.77 | MRGPRX4 (0.74) | MRGPRX4PTGER1NPC1HPGDRAB9A | |
| SCHEMBL13440174 | 0.76 | RXRA (0.70) | MRGPRX4PTGER1RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL10857748 | 0.76 | MRGPRX4 (0.61) | MRGPRX4PTGER1NPC1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877379-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | Astex Therapeutics Limited (GB) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006109085-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | ASTEX THERAPEUTICS LIMITED (GB) | 2006-10-19 | — | — | WO | disclosed |