Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP6 | P51161 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14400085 | 0.78 | FABP6 (0.49) | FABP6OPRL1EPHX2EPHX1TP53 | |
| SCHEMBL21088960 | 0.77 | GNAI3 (0.34) | ALDH1A1LMNA | |
| SCHEMBL22622636 | 0.76 | FABP6 (0.37) | FABP6OPRL1EPHX2EPHX1TP53 | |
| SCHEMBL12750868 | 0.74 | FABP6 (0.51) | FABP6OPRL1EPHX2EPHX1TP53 | |
| SCHEMBL190262 | 0.74 | ALDH1A1 (0.50) | FABP6OPRL1TP53ALDH1A1SMYD3 | |
| SCHEMBL23634820 | 0.73 | FABP6 (0.45) | FABP6OPRL1EPHX2EPHX1TP53 | |
| SCHEMBL477234 | 0.73 | TP53 (0.39) | FABP6OPRL1EPHX2EPHX1TP53 | |
| SCHEMBL12404039 | 0.71 | TP53 (0.46) | FABP6EPHX2EPHX1TP53ALDH1A1 | |
| SCHEMBL29259766 | 0.70 | TP53 (0.48) | FABP6EPHX2EPHX1TP53ALDH1A1 | |
| SCHEMBL28612237 | 0.70 | ALDH1A1 (0.40) | FABP6OPRL1TP53ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411387-A2 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLE SULFONAMIDES AND THEIR USE IN CANCER THERAPY | Pathway Therapeutics, Inc. (US) | 2012-02-01 | — | — | EP | claimed |
| EP-2411387-A2 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLE SULFONAMIDES AND THEIR USE IN CANCER THERAPY | Pathway Therapeutics, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010110685-A2 | PYRIMDDINYL AND 1,3,5-TRIAZINYL BENZIMTOAZOLE SULFONAMIDES AND THEIR USE IN CANCER THERAPY | PATHWAY THERAPEUTICS LIMITED (NZ) | 2010-09-30 | — | — | WO | disclosed |