Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.55 |
| ▸ | MPL | P40238 | 3/20 | 0.44 |
| ▸ | RBP4 | P02753 | 6/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772173 | 0.84 | KMO (0.50) | KMOMMP13 | |
| SCHEMBL4774543 | 0.81 | KMO (0.53) | KMO | |
| SCHEMBL3564371 | 0.80 | RXRA (0.47) | RXRARXRB | |
| SCHEMBL4772296 | 0.78 | SCN9A (0.51) | MMP13 | |
| SCHEMBL1796619 | 0.78 | GRM5 (0.44) | MMP13 | |
| SCHEMBL1798493 | 0.78 | GRM5 (0.43) | KMOMPLMMP13 | |
| SCHEMBL4772425 | 0.77 | KMO (0.54) | KMOMMP13KIF11RXRARXRB | |
| SCHEMBL4777638 | 0.76 | MCL1 (0.41) | KMORBP4MMP13 | |
| SCHEMBL4772052 | 0.75 | ALOX15 (0.46) | KMO | |
| SCHEMBL4777388 | 0.75 | GRM5 (0.44) | KMOMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101384554-B | Pyridine-2-carboxamide derivatives | HOFFMANN LA ROCHE | 2012-08-08 | — | — | CN | claimed |
| CN-101384554-A | Pyridine-2-carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | CN | claimed |
| EP-1987003-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | claimed |
| WO-2007093542-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | claimed |
| US-20070197553-A1 | 4-Aryl-pyridine-2-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. | 2007-08-23 | — | — | US | claimed |
| CN-101384554-B | Pyridine-2-carboxamide derivatives | HOFFMANN LA ROCHE | 2012-08-08 | — | — | CN | disclosed |
| CN-101384554-A | Pyridine-2-carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | CN | disclosed |
| EP-1987003-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093542-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | disclosed |
| US-20070197553-A1 | 4-Aryl-pyridine-2-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197553-A1 | 4-Aryl-pyridine-2-carboxyamide derivatives | GRM2, GRM1, GRM3 | KMO 1037/4885MPL 1888/4885RBP4 3108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.