Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780151 | 1.00 | KCNH2 (0.43) | KCNH2KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL4894834 | 0.90 | POLB (0.44) | KCNH2KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL4894830 | 0.90 | POLB (0.44) | KCNH2KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL4795657 | 0.90 | POLB (0.44) | KCNH2KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL4022116 | 0.89 | CYP2C9 (0.41) | KCNH2KMT2AALDH1A1MEN1DRD2 | |
| SCHEMBL4773635 | 0.88 | KCNH2 (0.40) | KCNH2KMT2AALDH1A1 | |
| SCHEMBL4775780 | 0.88 | KCNH2 (0.40) | KCNH2KMT2AALDH1A1 | |
| SCHEMBL4028327 | 0.87 | KMT2A (0.34) | KCNH2KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL4020474 | 0.87 | KMT2A (0.34) | KCNH2KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL4780721 | 0.87 | KIF11 (0.46) | KCNH2KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |