Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4894830 | 1.00 | POLB (0.44) | POLBALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL4894834 | 1.00 | POLB (0.44) | POLBALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL4780063 | 0.97 | ALDH1A1 (0.46) | POLBALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL4777781 | 0.97 | ALDH1A1 (0.46) | POLBALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL4776822 | 0.97 | ALDH1A1 (0.46) | POLBALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL4772529 | 0.90 | KCNH2 (0.43) | POLBALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL4780151 | 0.90 | KCNH2 (0.43) | POLBALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL4019805 | 0.89 | ALDH1A1 (0.41) | POLBALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL4022602 | 0.86 | POLB (0.41) | POLBALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL4775780 | 0.86 | KCNH2 (0.40) | ALDH1A1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |