Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773635 | 0.98 | KCNH2 (0.40) | KCNH2KIF11ALDH1A1LMNAKMT2A | |
| SCHEMBL4780207 | 0.93 | L3MBTL1 (0.37) | KCNH2KIF11ALDH1A1LMNAKMT2A | |
| SCHEMBL4772352 | 0.93 | L3MBTL1 (0.37) | KCNH2KIF11ALDH1A1LMNAKMT2A | |
| SCHEMBL4780721 | 0.90 | KIF11 (0.46) | KCNH2KIF11ALDH1A1LMNAKMT2A | |
| SCHEMBL4776368 | 0.90 | KIF11 (0.46) | KCNH2KIF11ALDH1A1LMNAKMT2A | |
| SCHEMBL4776377 | 0.88 | KCNH2 (0.42) | KCNH2KIF11ALDH1A1LMNAKMT2A | |
| SCHEMBL4778087 | 0.88 | KIF11 (0.47) | KCNH2KIF11 | |
| SCHEMBL4772529 | 0.88 | KCNH2 (0.43) | KCNH2ALDH1A1KMT2A | |
| SCHEMBL4780151 | 0.88 | KCNH2 (0.43) | KCNH2ALDH1A1KMT2A | |
| SCHEMBL4019541 | 0.87 | KCNH2 (0.36) | KCNH2KIF11ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |