Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27873480 | 0.94 | NAMPT (0.41) | NAMPTPOLBL3MBTL1SCD5VNN1 | |
| SCHEMBL27889764 | 0.94 | NAMPT (0.41) | NAMPTPOLBL3MBTL1SCD5VNN1 | |
| SCHEMBL4780190 | 0.94 | NAMPT (0.41) | NAMPTPOLBL3MBTL1SCD5VNN1 | |
| SCHEMBL26906148 | 0.86 | NAMPT (0.36) | NAMPTPOLBL3MBTL1SCD5VNN1 | |
| SCHEMBL26131508 | 0.86 | NAMPT (0.36) | NAMPTPOLBL3MBTL1SCD5VNN1 | |
| SCHEMBL18855618 | 0.85 | ALDH1A1 (0.43) | NAMPTRIPK1HPGDCA2 | |
| SCHEMBL21057424 | 0.84 | VNN1 (0.36) | NAMPTPOLBL3MBTL1SCD5VNN1 | |
| SCHEMBL20738584 | 0.84 | CHRM2 (0.41) | NAMPTSPRGAAHPGD | |
| SCHEMBL16794429 | 0.84 | NAMPT (0.36) | NAMPTPOLBL3MBTL1SCD5VNN1 | |
| SCHEMBL17901822 | 0.82 | HPGD (0.44) | NAMPTSCD5VNN1SPRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| CN-107531679-A | Aromatic amides analog derivative, its preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2018-01-02 | — | — | CN | disclosed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |