Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9948053 | 0.80 | GRM5 (0.47) | GRM5HTTMAPTSMN1; SMN2CYP2A6 | |
| SCHEMBL4158644 | 0.80 | GRM5 (0.40) | GRM5HTTMAPTSMN1; SMN2RAB9A | |
| SCHEMBL3722709 | 0.77 | GRM5 (0.48) | GRM5HTTMAPTSMN1; SMN2CYP2A6 | |
| SCHEMBL3665917 | 0.76 | CYP2A6 (0.54) | GRM5HTTMAPTSMN1; SMN2CYP2A6 | |
| SCHEMBL3802122 | 0.76 | GRM5 (0.44) | GRM5HTTMAPTSMN1; SMN2CYP2A6 | |
| SCHEMBL931245 | 0.74 | GRM5 (0.51) | GRM5BACE1HTTMAPTSMN1; SMN2 | |
| SCHEMBL25864597 | 0.72 | CYP3A4 (0.41) | MAPTCYP2A6 | |
| SCHEMBL4738215 | 0.71 | APP (0.49) | GRM5 | |
| SCHEMBL1477377 | 0.71 | GRM5 (0.49) | GRM5HTTCYP2A6RAB9A | |
| SCHEMBL8486570 | 0.70 | GRM5 (0.47) | GRM5HTTCYP2A6RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242973-B2 | Chromane compounds | COMENTIS, INC. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20150225386-A1 | CHROMANE COMPOUNDS | COMENTIS, INC. | 2015-08-13 | — | — | US | disclosed |
| EP-2854797-A2 | CHROMANE COMPOUNDS | Comentis, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8975415-B2 | Chromane compounds | COMENTIS, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| US-20140179695-A1 | CHROMANE COMPOUNDS | COMENTIS, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| WO-2013181202-A2 | CHROMANE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2013-12-05 | — | — | WO | disclosed |
| EP-1020445-B1 | FUSED PYRIDINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2008-08-13 | — | — | EP | disclosed |
| US-6875761-B2 | Certain 1,3-disubstituted isoquinoline derivatives | EISAI CO., LTD. (JP) | 2005-04-05 | — | — | US | disclosed |
| US-20040204421-A1 | Certain 1,3-disubstituted isoquinoline derivatives | EISAI CO., LTD. | 2004-10-14 | — | — | US | disclosed |
| US-6790844-B2 | MUSCLE RELAXANTS; ANTISEROTONINE AGENT | EISAI CO., LTD (JP) | 2004-09-14 | — | — | US | disclosed |
| US-20020013460-A1 | Condensed pyridine compound | EISAI CO., LTD | 2002-01-31 | — | — | US | disclosed |
| US-6340759-B1 | ANTISPASMODIC AGENTS | EISAI CO., LTD. (JP) | 2002-01-22 | — | — | US | disclosed |
| EP-1020445-A1 | FUSED PYRIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-07-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013460-A1 | Condensed pyridine compound | MUSK, HTR1A, PAX3 | GRM5 463/4885BACE1 4323/4885HTT 2446/4885 |
| US-20140179695-A1 | CHROMANE COMPOUNDS | BACE1, BACE2, APP | GRM5 1656/4885BACE1 1/4885HTT 385/4885 |
| US-20150225386-A1 | CHROMANE COMPOUNDS | BACE1, BACE2, APP | GRM5 993/4885BACE1 1/4885HTT 423/4885 |
| US-20040204421-A1 | Certain 1,3-disubstituted isoquinoline derivatives | MUSK, HTR1A, RYR1 | GRM5 376/4885BACE1 4623/4885HTT 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.