Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774815 | 0.73 | POLB (0.44) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL30740817 | 0.73 | HDAC8 (0.52) | ALDH1A1SMN1; SMN2LMNAMAPK1KMT2A | |
| SCHEMBL22068300 | 0.72 | CHRNA4 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL19425624 | 0.70 | SLC6A2 (0.50) | HPGDLMNAKCNMA1KMT2AMAPT | |
| SCHEMBL123068 | 0.68 | CA1 (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL30740745 | 0.68 | TBXA2R (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL8659315 | 0.67 | TTR (0.55) | ALDH1A1HPGDSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL30740729 | 0.67 | SMN1; SMN2 (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL363972 | 0.67 | MAOB (0.61) | ALDH1A1HPGDMAPK1KMT2AMEN1 | |
| SCHEMBL4135441 | 0.66 | TTR (0.75) | ALDH1A1HPGDLMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874749-A1 | FURAN COMPOUNDS USEFUL AS EPl RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006114272-A1 | FURAN COMPOUNDS USEFUL AS EPl RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-11-02 | — | — | WO | disclosed |