Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 5/20 | 0.33 |
| ▸ | DUT | P33316 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20519513 | 0.84 | LMNA (0.49) | LMNAMAOASLC6A2PKMMAPK1 | |
| SCHEMBL2288476 | 0.84 | LMNA (0.49) | LMNAMAOASLC6A2PKMMAPK1 | |
| SCHEMBL21428625 | 0.84 | LMNA (0.49) | LMNAMAOASLC6A2PKMMAPK1 | |
| SCHEMBL2518366 | 0.77 | MAOA (0.40) | LMNAMAOASLC6A2PKMMAPK1 | |
| SCHEMBL2518363 | 0.77 | MAOA (0.40) | LMNAMAOASLC6A2PKMMAPK1 | |
| SCHEMBL8842452 | 0.76 | CYP1A2 (0.42) | TOP2ADUT | |
| SCHEMBL8711625 | 0.76 | CYP1A2 (0.42) | TOP2ADUT | |
| SCHEMBL8842448 | 0.76 | CYP1A2 (0.42) | TOP2ADUT | |
| SCHEMBL18305983 | 0.75 | DUT (0.37) | TOP2ADUT | |
| SCHEMBL20211424 | 0.74 | TOP2A (0.45) | TOP2ADUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912977-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | Merck Frosst Canada Ltd. (CA) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007014454-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2007-02-08 | — | — | WO | disclosed |
| EP-1613621-A1 | PROSTAGLANDIN ANALOGS AS EP4 RECEPTOR AGONISTS | Merck Frosst Canada Ltd. (CA) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004085430-A1 | PROSTAGLANDIN ANALOGS AS EP4 RECEPTOR AGONISTS | MERCK FROSST CANADA LTD. (CA) | 2004-10-07 | — | — | WO | disclosed |