SCHEMBL4773133

SCHEMBL4773133

O=C(c1ccc(C(=O)C(F)(F)F)s1)N1CCC(C(=O)N2CCCC2)CC1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL3 Q96JM7 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
HDAC6 Q9UBN7 7/20 0.51
HDAC1 Q13547 6/20 0.51
CYP2C9 P11712 3/20 0.51
HDAC3 O15379 3/20 0.51
HPGD P15428 6/20 0.50
ALDH1A1 P00352 2/20 0.50
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
TSHR P16473 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
YEATS4 O95619 1/20 0.47
MLYCD O95822 1/20 0.47
POLB P06746 1/20 0.47
HDAC4 P56524 4/20 0.45
NOTUM Q6P988 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2202532 0.89 HPGD (0.59) L3MBTL3L3MBTL1HDAC6HDAC1CYP2C9
SCHEMBL17707579 0.85 HDAC6 (0.56) L3MBTL3L3MBTL1HDAC6HDAC1CYP2C9
SCHEMBL2204285 0.81 HDAC6 (0.55) L3MBTL3L3MBTL1HDAC6HDAC1CYP2C9
SCHEMBL2204120 0.81 HDAC6 (0.55) L3MBTL3L3MBTL1HDAC6HDAC1CYP2C9
SCHEMBL2202147 0.80 ALDH1A1 (0.60) HDAC6HDAC1CYP2C9HDAC3ALDH1A1
SCHEMBL2200890 0.78 ALDH1A1 (0.61) HDAC6HDAC1CYP2C9HDAC3HPGD
SCHEMBL17707597 0.77 L3MBTL3 (0.61) L3MBTL3L3MBTL1HDAC6HDAC1CYP2C9
SCHEMBL2200435 0.75 HDAC6 (0.59) L3MBTL3L3MBTL1HDAC6HDAC1CYP2C9
Trifluoroacetic Acid SCHEMBL2203749 0.74 L3MBTL1 (0.57) L3MBTL3L3MBTL1HDAC6HDAC1CYP2C9
SCHEMBL2203217 0.74 HDAC6 (0.52) L3MBTL3L3MBTL1HDAC6HDAC1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1926721-B1 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS MSD ITALIA SRL (IT) 2016-05-04 EP claimed
EP-1926721-B1 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS MSD ITALIA SRL (IT) 2016-05-04 EP disclosed
EP-1926721-A2 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) 2008-06-04 EP disclosed
WO-2007029035-A2 THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2007-03-15 WO disclosed