Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 6/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL482195 | 1.00 | ABCC9 (0.50) | ABCC9PKMGAACA2RAPGEF4 | |
| SCHEMBL482197 | 1.00 | ABCC9 (0.50) | ABCC9PKMGAACA2RAPGEF4 | |
| SCHEMBL3442031 | 0.87 | ABCC9 (0.48) | ABCC9SMN1; SMN2KCNA5HTR6 | |
| SCHEMBL482008 | 0.87 | ABCC9 (0.48) | ABCC9SMN1; SMN2KCNA5HTR6 | |
| SCHEMBL7820065 | 0.85 | MAPT (0.53) | PKMGAALMNATDP1 | |
| SCHEMBL481908 | 0.85 | ABCC9 (0.52) | ABCC9LMNAHTT | |
| SCHEMBL4716582 | 0.85 | ABCC9 (0.52) | ABCC9LMNAHTT | |
| SCHEMBL482380 | 0.85 | ABCC9 (0.52) | ABCC9LMNAHTT | |
| SCHEMBL7821131 | 0.84 | PGR (0.48) | LMNAHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL7258457 | 0.83 | HTR2B (0.41) | GAAHTTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940516-A2 | BENZOPYRAN AND PYRANOPYRIDINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | Janssen Pharmaceutica, N.V. (BE) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007027780-A2 | BENZOPYRAN AND PYRANOPYRIDINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-08 | — | — | WO | disclosed |