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Sugi Predict / Compounds / SCHEMBL4773660

SCHEMBL4773660

SCHEMBL4773660

CCN(c1ncc2c(=O)c(C(N)=O)cn(-c3ccc4c(c3)CCC4)c2n1)C1CCCCN1

nearest known ligand 0.56

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 20/20 0.56
▸ NTRK1 P04629 3/20 0.54
▸ KIT P10721 3/20 0.54
▸ SRC P12931 3/20 0.54
▸ FLT3 P36888 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4775457 0.91 CSF1R (0.57) CSF1RNTRK1KITSRCFLT3
SCHEMBL4768393 0.88 CSF1R (0.47) CSF1RNTRK1KITSRCFLT3
SCHEMBL4775340 0.85 CSF1R (0.48) CSF1RNTRK1KITSRCFLT3
SCHEMBL4777730 0.82 CSF1R (0.57) CSF1RNTRK1KITSRCFLT3
SCHEMBL4771887 0.79 CSF1R (0.40) CSF1RKITSRCFLT3
SCHEMBL4763078 0.78 CSF1R (0.58) CSF1RNTRK1KITSRCFLT3
SCHEMBL4769014 0.78 CSF1R (0.42) CSF1R
SCHEMBL4775827 0.76 CSF1R (0.59) CSF1RNTRK1KITSRCFLT3
SCHEMBL4572935 0.76 CSF1R (0.59) CSF1RNTRK1KITSRCFLT3
SCHEMBL4773616 0.75 CSF1R (0.43) CSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945637-A1 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2008-07-23 — — EP disclosed
WO-2007033137-A1 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA, N.V. (BE) 2007-03-22 — — WO disclosed