Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 18/20 | 0.63 |
| ▸ | HRH1 | P35367 | 18/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 18/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 2/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771775 | 0.95 | ADRA1A (0.61) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2819064 | 0.84 | HRH1 (0.68) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2822110 | 0.83 | HRH1 (0.67) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2820250 | 0.82 | HRH1 (0.67) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL10372558 | 0.81 | ADRA1A (0.79) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL2780705 | 0.81 | HRH1 (0.66) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL10375081 | 0.80 | ADRA1A (0.75) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL6886542 | 0.80 | ADRA1A (0.84) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| Azelastine SCHEMBL6886545 | 0.80 | ADRA1A (0.84) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL4662127 | 0.80 | HRH1 (0.63) | ADRA1AHRH1ADRA1BHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007735-A1 | 2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS | Glaxo Group Limited (GB) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007122156-A9 | 2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2007122156-A1 | 2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-11-01 | — | — | WO | disclosed |