Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020371 | 0.87 | KIF11 (0.45) | KMT2AMEN1ALDH1A1KIF11MAPK1 | |
| SCHEMBL4780207 | 0.86 | L3MBTL1 (0.37) | KMT2AMEN1ALDH1A1KIF11MAPK1 | |
| SCHEMBL4772352 | 0.86 | L3MBTL1 (0.37) | KMT2AMEN1ALDH1A1KIF11MAPK1 | |
| SCHEMBL4776377 | 0.86 | KCNH2 (0.42) | KMT2AMEN1ALDH1A1KIF11LMNA | |
| SCHEMBL4020618 | 0.86 | KIF11 (0.41) | KMT2AMEN1ALDH1A1GAAKIF11 | |
| SCHEMBL4019539 | 0.85 | KCNH2 (0.36) | KMT2AMEN1ALDH1A1GAAKIF11 | |
| SCHEMBL4019541 | 0.85 | KCNH2 (0.36) | KMT2AMEN1ALDH1A1GAAKIF11 | |
| SCHEMBL4772648 | 0.85 | KIF11 (0.44) | KMT2AMEN1ALDH1A1KIF11MAPT | |
| SCHEMBL4021208 | 0.85 | GRIN2B (0.38) | KMT2AMEN1ALDH1A1KIF11MAPT | |
| SCHEMBL4021213 | 0.85 | GRIN2B (0.38) | KMT2AMEN1ALDH1A1KIF11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |