Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780207 | 1.00 | L3MBTL1 (0.37) | L3MBTL1KCNH2KIF11RORCCCR5 | |
| SCHEMBL4775780 | 0.93 | KCNH2 (0.40) | KCNH2KIF11RORCCCR5KMT2A | |
| SCHEMBL4773635 | 0.93 | KCNH2 (0.40) | KCNH2KIF11RORCCCR5KMT2A | |
| SCHEMBL4776377 | 0.91 | KCNH2 (0.42) | KCNH2KIF11RORCMEN1KMT2A | |
| SCHEMBL4019541 | 0.89 | KCNH2 (0.36) | KCNH2KIF11RORCCCR5SLC6A1 | |
| SCHEMBL4772648 | 0.89 | KIF11 (0.44) | KCNH2KIF11RORCCCR5SLC6A1 | |
| SCHEMBL4019539 | 0.89 | KCNH2 (0.36) | KCNH2KIF11RORCCCR5SLC6A1 | |
| SCHEMBL4020618 | 0.88 | KIF11 (0.41) | L3MBTL1KCNH2KIF11RORCMEN1 | |
| SCHEMBL4026452 | 0.88 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4776368 | 0.87 | KIF11 (0.46) | KCNH2KIF11RORCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |