Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238950 | 0.79 | CYP11B2 (0.36) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL1816723 | 0.77 | FGFR4 (0.43) | MEN1KMT2ASMN1; SMN2FGFR4NOTUM | |
| SCHEMBL23860818 | 0.73 | FGFR4 (0.40) | SMN1; SMN2FGFR4NOTUM | |
| SCHEMBL3948225 | 0.69 | HDAC1 (0.61) | KDM4EHSD17B10SMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL30002194 | 0.68 | MAOA (0.38) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL6635128 | 0.68 | MAOA (0.38) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL22397505 | 0.68 | IDO1 (0.37) | HSD17B10SMN1; SMN2NOTUMMAPTTSHR | |
| SCHEMBL3656037 | 0.67 | PDK1 (0.59) | KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL29029085 | 0.67 | CYP11B2 (0.40) | ALDH1A1KDM4EHSD17B10SMN1; SMN2FGFR4 | |
| SCHEMBL3398754 | 0.67 | GRM5 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732933-B1 | COMPOUNDS FOR TREATING DYSLIPIDEMIA | LILLY CO ELI (US) | 2008-07-23 | — | — | EP | disclosed |