Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633594 | 0.85 | FGFR1 (0.48) | ADORA3RAB9AGSK3BFGFR1FGFR2 | |
| SCHEMBL4632585 | 0.84 | KCNK3 (0.41) | KCNK3KCNK9ADORA3LCKRAB9A | |
| SCHEMBL4631749 | 0.83 | CDK2 (0.49) | KCNK3GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4632650 | 0.82 | HDAC6 (0.42) | KCNK3KCNK9RAB9AFGFR1FGFR2 | |
| SCHEMBL4632541 | 0.81 | HPGD (0.42) | KCNK3KCNK9ADORA3LCKRAB9A | |
| SCHEMBL4632622 | 0.80 | HDAC6 (0.53) | KCNK9ADORA3RAB9AHDAC6CDK7 | |
| SCHEMBL4631794 | 0.79 | AURKA (0.46) | KCNK3RAB9AFGFR1FGFR3CDK7 | |
| SCHEMBL4632536 | 0.79 | FLT3 (0.51) | KCNK3RAB9AGSK3BFGFR1FGFR2 | |
| SCHEMBL4631888 | 0.79 | NPC1 (0.42) | ADORA3RAB9AADORA1FGFR1FGFR2 | |
| SCHEMBL4632668 | 0.79 | CDK7 (0.50) | KCNK3RAB9ACDK7CDK2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |