Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 2/20 | 0.50 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633594 | 0.89 | FGFR1 (0.48) | CDK7PIM3CCNA2CDK2CCNA1 | |
| SCHEMBL4631749 | 0.86 | CDK2 (0.49) | CDK7PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4631709 | 0.84 | CDK7 (0.54) | CDK7PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4631794 | 0.83 | AURKA (0.46) | CDK7PRKAA1MAPK1KCNK3PIM3 | |
| SCHEMBL4632650 | 0.81 | HDAC6 (0.42) | CDK7KCNK3PIM1KDM4EKMT2A | |
| SCHEMBL4633322 | 0.81 | SMN1; SMN2 (0.53) | CDK7KCNK3KMT2AROCK2TSHR | |
| SCHEMBL4632541 | 0.80 | HPGD (0.42) | CDK7KCNK3KMT2ACYP1A2CCNA2 | |
| SCHEMBL4633224 | 0.80 | CA1 (0.46) | MAPK1KCNK3LMNAKDM4EKMT2A | |
| SCHEMBL4632622 | 0.79 | HDAC6 (0.53) | CDK7KDM4EKMT2ACYP1A2CYP2C9 | |
| SCHEMBL4775168 | 0.79 | KCNK3 (0.40) | CDK7KCNK3PIM3CDK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |