Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 10/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 9/20 | 0.52 |
| ▸ | FLT3 | P36888 | 6/20 | 0.52 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.52 |
| ▸ | CDC7 | O00311 | 5/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | FES | P07332 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773025 | 0.87 | CYP2A6 (0.47) | JAK3LRRK2CYP2A6PIK3CANPC1 | |
| SCHEMBL4772988 | 0.83 | CYP2A6 (0.45) | EGFRCYP2A6NPC1TP53PKM | |
| SCHEMBL30085793 | 0.80 | CDC7 (0.48) | MERTKTYRO3FLT3CDC7CHEK1 | |
| SCHEMBL30085671 | 0.80 | CDC7 (0.48) | MERTKTYRO3FLT3CDC7CHEK1 | |
| SCHEMBL28895048 | 0.80 | CDC7 (0.48) | MERTKTYRO3FLT3CDC7CHEK1 | |
| SCHEMBL28895052 | 0.80 | CDC7 (0.48) | MERTKTYRO3FLT3CDC7CHEK1 | |
| SCHEMBL28895160 | 0.80 | CDC7 (0.48) | MERTKTYRO3FLT3CDC7CHEK1 | |
| SCHEMBL4878463 | 0.79 | SYK (0.47) | FLT3CDC7CHEK1MAPK13PDPK1 | |
| SCHEMBL4773261 | 0.79 | SYK (0.47) | FLT3CDC7CHEK1MAPK13PDPK1 | |
| SCHEMBL4775400 | 0.78 | GBA1 (0.53) | JAK2JAK3CYP2A6NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878733-A1 | Pyrimidine derivatives as ALK-5 inhibitors | Novartis AG (CH) | 2008-01-16 | — | — | EP | disclosed |