Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4772137 | 0.94 | HRH3 (0.44) | HRH3MEN1KMT2ANPC1POLB | |
| SCHEMBL4771074 | 0.81 | HRH3 (0.64) | HRH3KMT2ANPC1POLBRAB9A | |
| SCHEMBL4772144 | 0.78 | HRH3 (0.42) | HRH3MEN1KMT2ANPC1POLB | |
| SCHEMBL4768500 | 0.76 | HRH3 (0.57) | HRH3NPC1RAB9ATMPRSS2 | |
| SCHEMBL4772163 | 0.75 | NPC1 (0.57) | HRH3KMT2ANPC1POLBRAB9A | |
| Trifluoroacetic Acid SCHEMBL4767946 | 0.75 | HRH3 (0.56) | HRH3KMT2ANPC1POLBRAB9A | |
| SCHEMBL4765424 | 0.74 | HRH3 (0.47) | HRH3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4767955 | 0.74 | HRH3 (0.50) | HRH3NPC1RAB9ACYP2D6 | |
| SCHEMBL4773028 | 0.74 | RAB9A (0.60) | HRH3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4767410 | 0.73 | MAPT (0.57) | HRH3MEN1KMT2ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |