Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | PEPD | P12955 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28482911 | 0.81 | TGM2 (0.42) | MAPTGAASMN1; SMN2RAB9AP2RX4 | |
| SCHEMBL858689 | 0.76 | MAPT (0.45) | MAPTGAASMN1; SMN2RAB9AP2RX4 | |
| Hydrochloric Acid SCHEMBL27291094 | 0.74 | MAPT (0.44) | MAPTGAASMN1; SMN2RAB9AP2RX4 | |
| SCHEMBL28299662 | 0.74 | MAPT (0.44) | MAPTGAASMN1; SMN2RAB9A | |
| SCHEMBL8330072 | 0.73 | MAPT (0.47) | MAPTGAASMN1; SMN2RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL8332139 | 0.72 | MAPT (0.45) | MAPTGAASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL20987114 | 0.72 | MAPT (0.45) | MAPTGAASMN1; SMN2RAB9AP2RX4 | |
| SCHEMBL28658376 | 0.72 | MAPT (0.41) | MAPTGAASMN1; SMN2RAB9AP2RX4 | |
| SCHEMBL27819720 | 0.71 | MAPT (0.48) | MAPTGAASMN1; SMN2RAB9AP2RX4 | |
| SCHEMBL14691822 | 0.69 | MAPT (0.45) | MAPTGAASMN1; SMN2RAB9AP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001035899-A9 | INHIBITORS OF HELICOBACTER PYLORI INDUCED GASTROINTESTINAL DISEASES | AXXIMA PHARMACEUTICALS AG (DE) | 2002-09-19 | — | — | WO | claimed |
| EP-1229925-A2 | INHIBITORS OF HELICOBACTER PYLORI INDUCED GASTROINTESTINAL DISEASES | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2002-08-14 | — | — | EP | claimed |
| WO-2001035899-A2 | INHIBITORS OF HELICOBACTER PYLORI INDUCED GASTROINTESTINAL DISEASES | AXXIMA PHARMACEUTICALS AG (DE) | 2001-05-25 | — | — | WO | claimed |
| EP-2002837-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1237888-B1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | disclosed |
| US-6852745-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-08 | — | — | US | disclosed |
| US-6835741-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-28 | — | — | US | disclosed |
| US-6638937-B2 | As antihypertensive agents; for therapy of disorders related to renal, glomerular and mesangial cell function; therapy of endotoxemia or endotoxin shock as well as hemorrhagic shock; useful in alleviation of pain associated cancer | BRISTOL-MYERS SQUIBB CO. | 2003-10-28 | — | — | US | disclosed |
| WO-2001035899-A9 | INHIBITORS OF HELICOBACTER PYLORI INDUCED GASTROINTESTINAL DISEASES | AXXIMA PHARMACEUTICALS AG (DE) | 2002-09-19 | — | — | WO | disclosed |
| EP-1237888-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1229925-A2 | INHIBITORS OF HELICOBACTER PYLORI INDUCED GASTROINTESTINAL DISEASES | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2002-08-14 | — | — | EP | disclosed |
| EP-1094816-A4 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | disclosed |
| CN-1308536-A | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL MYERS SQUIBB CO (US) | 2001-08-15 | — | — | CN | disclosed |
| WO-2001044239-A2 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2001-06-21 | — | — | WO | disclosed |
| WO-2001035899-A2 | INHIBITORS OF HELICOBACTER PYLORI INDUCED GASTROINTESTINAL DISEASES | AXXIMA PHARMACEUTICALS AG (DE) | 2001-05-25 | — | — | WO | disclosed |
| EP-1094816-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001389-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-01-13 | — | — | WO | disclosed |