Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.48 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.34 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.34 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL981060 | 0.80 | IMPDH2 (0.67) | IMPDH2IMPDH1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL11924851 | 0.73 | IMPDH2 (0.52) | IMPDH2IMPDH1CCNT1CDK9HASPIN | |
| SCHEMBL24612211 | 0.70 | IMPDH2 (0.50) | IMPDH2IMPDH1CCNT1CDK9HASPIN | |
| SCHEMBL27729278 | 0.68 | IMPDH2 (0.48) | IMPDH2IMPDH1CCNT1CDK9HASPIN | |
| SCHEMBL578915 | 0.67 | IMPDH2 (0.59) | IMPDH2IMPDH1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL18412741 | 0.67 | IMPDH2 (0.51) | IMPDH2IMPDH1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL27708665 | 0.65 | IMPDH2 (1.00) | IMPDH2IMPDH1SLC6A4 | |
| SCHEMBL14038673 | 0.65 | IMPDH2 (0.51) | IMPDH2IMPDH1CCNT1CDK9HASPIN | |
| SCHEMBL4906806 | 0.65 | IMPDH2 (0.50) | IMPDH2IMPDH1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL12996747 | 0.64 | IMPDH2 (0.56) | IMPDH2IMPDH1PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984332-A2 | METHODS FOR TREATING HEPATITIS C | PTC Therapeutics, Inc. (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084413-A2 | METHODS FOR TREATING HEPATITIS C | PTC THERAPEUTICS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |