Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776952 | 0.83 | LMNA (0.46) | ALDH1A1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL4771297 | 0.81 | NPSR1 (0.46) | KDM4EALDH1A1TSHRNPSR1MEN1 | |
| SCHEMBL4779189 | 0.80 | NPSR1 (0.43) | ALDH1A1SMN1; SMN2TSHRNPSR1MEN1 | |
| SCHEMBL4776309 | 0.77 | NPSR1 (0.42) | ALDH1A1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL4773595 | 0.76 | ALDH1A1 (0.43) | KDM4EALDH1A1SMN1; SMN2TSHRNPSR1 | |
| SCHEMBL4770304 | 0.74 | NPSR1 (0.39) | KDM4EALDH1A1TSHRNPSR1MEN1 | |
| SCHEMBL4775611 | 0.72 | NPSR1 (0.45) | ALDH1A1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL4778604 | 0.70 | NPSR1 (0.46) | KDM4EALDH1A1TSHRNPSR1MEN1 | |
| SCHEMBL11955709 | 0.69 | NPSR1 (0.59) | ALDH1A1SMN1; SMN2TSHRNPSR1MEN1 | |
| SCHEMBL4609707 | 0.69 | MAPT (0.47) | KDM4EALDH1A1TSHRNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | disclosed |