Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020589 | 1.00 | RORC (0.43) | RORCKMT2AMEN1KCNH2TSHR | |
| SCHEMBL4026119 | 0.92 | SLC18A3 (0.45) | RORCKMT2AMEN1KCNH2ALDH1A1 | |
| SCHEMBL4024282 | 0.92 | SLC18A3 (0.45) | RORCKMT2AMEN1KCNH2ALDH1A1 | |
| SCHEMBL4772340 | 0.84 | KMT2A (0.48) | RORCKMT2AMEN1KCNH2ALDH1A1 | |
| SCHEMBL4019373 | 0.84 | KMT2A (0.46) | RORCKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4026548 | 0.84 | KMT2A (0.46) | RORCKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4019381 | 0.84 | KMT2A (0.46) | RORCKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4772338 | 0.81 | HRH3 (0.45) | RORCKMT2AMEN1KCNH2ALDH1A1 | |
| SCHEMBL4021931 | 0.81 | ALDH1A1 (0.55) | KMT2AMEN1TSHRALDH1A1LMNA | |
| SCHEMBL4774189 | 0.81 | NTRK1 (0.43) | RORCKMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |