Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16969444 | 0.69 | POLB (0.47) | POLBRPS6KB2SMN1; SMN2MEN1MAPT | |
| SCHEMBL558390 | 0.67 | RAB9A (0.38) | POLBKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL3545 | 0.65 | L3MBTL1 (0.57) | POLBRPS6KB2SMN1; SMN2MEN1MAPT | |
| SCHEMBL16291133 | 0.65 | L3MBTL1 (0.57) | POLBRPS6KB2SMN1; SMN2MEN1MAPT | |
| SCHEMBL1906119 | 0.63 | POLB (0.41) | POLBSMN1; SMN2MEN1MAPTKMT2A | |
| Ammonia Solution, Strong SCHEMBL34467257 | 0.63 | L3MBTL1 (0.55) | POLBRPS6KB2SMN1; SMN2MEN1MAPT | |
| Fluoride SCHEMBL491501 | 0.63 | L3MBTL1 (0.55) | POLBRPS6KB2SMN1; SMN2MEN1MAPT | |
| Benzene SCHEMBL29089513 | 0.63 | L3MBTL1 (0.55) | POLBRPS6KB2SMN1; SMN2MEN1MAPT | |
| Hydrogen Sulfide SCHEMBL22588115 | 0.63 | L3MBTL1 (0.55) | POLBRPS6KB2SMN1; SMN2MEN1MAPT | |
| SCHEMBL29776515 | 0.63 | L3MBTL1 (0.55) | POLBRPS6KB2SMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4559335-A | 3-Acylamino-1-carboxymethyloxy (or thio) carbonyl-2-azetidinones | E. R. SQUIBB & SONS, INC. (US) | 1985-12-17 | — | — | US | claimed |
| US-4551277-A | 4-(3-Acylamino-2-oxo-1-azetidinyl)-4-oxo-2-butenoic acid | E. R. SQUIBB & SONS, INC. (US) | 1985-11-05 | — | — | US | claimed |
| EP-1899333-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS INHIBITORS OF BETA-ADRENERGIC RECEPTOR KINASE 1 | Sanofi-Aventis (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007000241-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS INHIBITORS OF BETA-ADRENERGIC RECEPTOR KINASE 1 | SANOFI-AVENTIS (DE) | 2007-01-04 | — | — | WO | disclosed |