Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 4/20 | 0.33 |
| ▸ | HTR1A | P08908 | 6/20 | 0.32 |
| ▸ | DRD1 | P21728 | 6/20 | 0.32 |
| ▸ | DRD4 | P21917 | 6/20 | 0.32 |
| ▸ | DRD5 | P21918 | 6/20 | 0.32 |
| ▸ | DRD3 | P35462 | 6/20 | 0.32 |
| ▸ | DRD2 | P14416 | 5/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESRRB | O95718 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751428 | 0.90 | KIF11 (0.34) | HTR1ADRD1DRD4DRD5DRD3 | |
| SCHEMBL4026066 | 0.89 | ESR1 (0.32) | KDM2BMEN1KMT2AESR1 | |
| SCHEMBL4809484 | 0.87 | ADRB2 (0.33) | HTR1ADRD1DRD4DRD5DRD3 | |
| SCHEMBL4025458 | 0.86 | NPC1 (0.36) | KDM2BMEN1KMT2A | |
| SCHEMBL4751290 | 0.84 | ESRRG (0.34) | ESRRGHTR1ADRD1DRD4DRD5 | |
| SCHEMBL4024173 | 0.84 | KDM2B (0.33) | KDM2BMEN1KMT2A | |
| SCHEMBL4026418 | 0.83 | KDM1A (0.32) | KDM2B | |
| SCHEMBL4020633 | 0.81 | MEN1 (0.35) | ESRRGKDM2BMEN1KMT2A | |
| SCHEMBL4029040 | 0.81 | DRD3 (0.35) | HTR1ADRD1DRD4DRD5DRD3 | |
| SCHEMBL4019458 | 0.80 | DPP4 (0.35) | ESRRGHTR1ADRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |