Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767615 | 0.93 | NR1H3 (0.41) | TRPM8GPBAR1P2RX7OXTRPTGDR2 | |
| SCHEMBL4777521 | 0.90 | GPBAR1 (0.42) | TRPM8GPBAR1P2RX7OXTR | |
| SCHEMBL4771001 | 0.78 | ALDH1A1 (0.36) | TRPM8GPBAR1P2RX7OXTR | |
| SCHEMBL4793541 | 0.78 | KCNH2 (0.42) | TRPM8P2RX7PDK1CYP1A2CYP3A4 | |
| SCHEMBL4767613 | 0.78 | NAMPT (0.46) | P2RX7 | |
| SCHEMBL4767893 | 0.77 | TRPM8 (0.37) | TRPM8GPBAR1OXTRCYP1A2CYP3A4 | |
| SCHEMBL4771084 | 0.77 | GPBAR1 (0.37) | TRPM8GPBAR1P2RX7OXTR | |
| SCHEMBL4777432 | 0.77 | TRPM8 (0.37) | TRPM8GPBAR1P2RX7OXTR | |
| SCHEMBL4777539 | 0.76 | GPBAR1 (0.36) | TRPM8GPBAR1P2RX7OXTR | |
| SCHEMBL4777438 | 0.76 | TRPM8 (0.36) | TRPM8GPBAR1OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | claimed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |