Sugi Predict

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SCHEMBL4767893

SCHEMBL4767893

CCOC(=O)CCS(=O)(=O)N(Cc1cccc(Cl)c1Cl)c1ccc(C(=O)N(C)c2ccc(C(F)(F)F)nc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 6/20 0.37
▸ LMNA P02545 2/20 0.37
▸ HPGD P15428 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ S1PR4 O95977 1/20 0.37
▸ TP53 P04637 1/20 0.37
▸ S1PR1 P21453 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ STAT3 P40763 1/20 0.37
▸ STAT1 P42224 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ TLR9 Q9NR96 1/20 0.37
▸ GPBAR1 Q8TDU6 5/20 0.36
▸ GRM2 Q14416 2/20 0.36
▸ SDHB P21912 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4767890 0.86 GAA (0.45) TRPM8LMNASMN1; SMN2NPSR1GAA
SCHEMBL4771084 0.85 GPBAR1 (0.37) TRPM8LMNASMN1; SMN2GPBAR1ALDH1A1
SCHEMBL4777539 0.83 GPBAR1 (0.36) TRPM8LMNASMN1; SMN2GPBAR1ALDH1A1
SCHEMBL4777438 0.79 TRPM8 (0.36) TRPM8GPBAR1ALDH1A1GAAOXTR
SCHEMBL4777432 0.78 TRPM8 (0.37) TRPM8GPBAR1ALDH1A1GAAOXTR
SCHEMBL4777415 0.78 HPGD (0.42) LMNAHPGDKMT2AS1PR4TP53
SCHEMBL4776918 0.77 TRPM8 (0.41) TRPM8GPBAR1CYP1A2CYP3A4CYP2C19
SCHEMBL4777521 0.77 GPBAR1 (0.42) TRPM8LMNASMN1; SMN2GPBAR1ALDH1A1
SCHEMBL4767615 0.77 NR1H3 (0.41) TRPM8HPGDKMT2ASMN1; SMN2GPBAR1
SCHEMBL4771001 0.74 ALDH1A1 (0.36) TRPM8GPBAR1ALDH1A1GAAOXTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1942888-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS Cytokinetics, Inc. (US) 2008-07-16 — — EP claimed
US-20070135435-A1 Certain chemical entities, compositions, and methods CYTOKINETICS, INCORPORATED 2007-06-14 — — US claimed
WO-2007056078-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INC. (US) 2007-05-18 — — WO claimed
EP-1942888-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS Cytokinetics, Inc. (US) 2008-07-16 — — EP disclosed
US-20070135435-A1 Certain chemical entities, compositions, and methods CYTOKINETICS, INCORPORATED 2007-06-14 — — US disclosed
WO-2007056078-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INC. (US) 2007-05-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070135435-A1 Certain chemical entities, compositions, and methods KIF5B, KIF2C, PLK1 TRPM8 3499/4885LMNA 1022/4885HPGD 2681/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.