Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 4/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.31 |
| ▸ | ACACB | O00763 | 3/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775579 | 0.73 | MEN1 (0.41) | ACACBACACAKDM4EALDH1A1MEN1 | |
| SCHEMBL3652692 | 0.60 | REN (0.44) | KDM4EALDH1A1 | |
| SCHEMBL5599357 | 0.59 | ACACB (0.63) | SMN1; SMN2ACACBACACAKDM4EALDH1A1 | |
| SCHEMBL3725442 | 0.58 | ERN1 (0.48) | MAPK1KDM4EALDH1A1TSHRMEN1 | |
| SCHEMBL15859178 | 0.57 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9098174 | 0.57 | INPPL1 (0.42) | MAPK1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL469900 | 0.56 | DRD2 (0.53) | SMN1; SMN2ACACBACACAKDM4EMEN1 | |
| SCHEMBL20772370 | 0.56 | HSD17B2 (0.43) | SMN1; SMN2KDM4EALDH1A1TSHRMEN1 | |
| SCHEMBL23640213 | 0.56 | MEN1 (0.58) | MAPK1SMN1; SMN2ESR1ESR2KDM4E | |
| SCHEMBL14604954 | 0.56 | MAOB (0.65) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | claimed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | claimed |