Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 18/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 17/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776759 | 0.84 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4777308 | 0.73 | SLC6A4 (0.45) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL5571822 | 0.71 | ALDH1A1 (0.42) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL16475935 | 0.69 | CPN1 (0.47) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4774929 | 0.68 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4792287 | 0.67 | REN (0.38) | SLC6A4SLC6A2REN | |
| SCHEMBL4775167 | 0.65 | KDM4E (0.39) | KCNH2 | |
| SCHEMBL4776560 | 0.64 | RECQL (0.44) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL27746280 | 0.62 | SLC6A2 (0.48) | SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL4768070 | 0.62 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |