SCHEMBL4777702

SCHEMBL4777702

NC(=O)c1nsc2cc(Br)ccc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.39
CDK5 Q00535 3/20 0.38
PDGFRA P16234 1/20 0.38
TYRO3 Q06418 1/20 0.38
DYRK1A Q13627 3/20 0.37
RAB9A P51151 2/20 0.37
NPC1 O15118 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
PARP1 P09874 1/20 0.37
PIM1 P11309 2/20 0.37
PRKACA P17612 2/20 0.37
CSNK1A1 P48729 2/20 0.37
CLK2 P49760 2/20 0.37
GSK3A P49840 2/20 0.37
GSK3B P49841 2/20 0.37
RPS6KA3 P51812 2/20 0.37
MAP4K2 Q12851 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL280594 0.87 PLG (0.39) DGAT1CDK5DYRK1ARAB9ANPC1
SCHEMBL30209249 0.85 RXFP1 (0.41) CDK5PDGFRATYRO3DYRK1ARAB9A
SCHEMBL260308 0.85 RXFP1 (0.41) CDK5PDGFRATYRO3DYRK1ARAB9A
SCHEMBL24898414 0.80 BCKDK (0.40) CDK5DYRK1APARP1PIM1PRKACA
SCHEMBL12211160 0.80 BCL2L1 (0.40) DYRK1ARAB9ANPC1PARP1ICAM1
SCHEMBL1096910 0.80 ELANE (0.46) DYRK1ARAB9ANPC1CYP1A2CYP3A4
SCHEMBL14352536 0.76 EPAS1 (0.37) CDK5PDGFRATYRO3DYRK1ARAB9A
SCHEMBL492447 0.76 GABRA1 (0.39) CDK5PDGFRATYRO3DYRK1ARAB9A
SCHEMBL492013 0.76 ELANE (0.49) RAB9ANPC1CYP1A2CYP2C9CYP2C19
SCHEMBL4774968 0.76 SMN1; SMN2 (0.45) DYRK1ARAB9ANPC1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3728199-B1 PESTICIDAL COMPOUNDS BASF SE (DE) 2025-05-14 EP disclosed
CN-111491925-B Pesticidal compounds 巴斯夫欧洲公司 2023-12-29 CN disclosed
US-11512054-B2 Pesticidal compounds BASF SE (DE) 2022-11-29 US disclosed
US-20210070713-A1 PESTICIDAL COMPOUNDS BASF SE (DE) 2021-03-11 US disclosed
EP-3728199-A1 PESTICIDAL COMPOUNDS BASF SE (DE) 2020-10-28 EP disclosed
CN-111491925-A Pesticidal compounds 巴斯夫欧洲公司 2020-08-04 CN disclosed
WO-2017128896-A1 FXR AGONIST AND PREPARATION METHOD AND USE THEREOF 江苏豪森药业集团有限公司 2017-08-03 WO disclosed
EP-1991531-A1 CINNOLINE AND QUINOXALINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS Amgen Inc. (US) 2008-11-19 EP disclosed
EP-1991530-A1 CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS Amgen Inc. (US) 2008-11-19 EP disclosed
US-20070287707-A1 Phosphodiesterase 10 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2007-12-13 US disclosed
US-20070265256-A1 Phosphodiesterase 10 inhibitors AMGEN INC. 2007-11-15 US disclosed
WO-2007100880-A1 CINNOLINE AND QUINAZOLINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS AMGEN INC. (US) 2007-09-07 WO disclosed
WO-2007098169-A1 CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS AMGEN INC. (US) 2007-08-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210070713-A1 PESTICIDAL COMPOUNDS CAT, NIT2, PNMT DGAT1 2883/4885CDK5 1349/4885PDGFRA 4515/4885
US-20070265256-A1 Phosphodiesterase 10 inhibitors PDE7A, PDE7B, PDE10A DGAT1 1019/4885CDK5 433/4885PDGFRA 3496/4885
US-20070287707-A1 Phosphodiesterase 10 inhibitors PDE7A, PDE7B, PDE10A DGAT1 1016/4885CDK5 548/4885PDGFRA 3587/4885
US-11512054-B2 Pesticidal compounds CAT, NIT2, PNMT DGAT1 2883/4885CDK5 1349/4885PDGFRA 4515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.