Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777534 | 0.88 | USP30 (0.52) | MEN1KMT2AALDH1A1 | |
| SCHEMBL5567872 | 0.81 | DRD2 (0.59) | MEN1KMT2AALDH1A1GAAPOLB | |
| SCHEMBL4777640 | 0.81 | DRD2 (0.59) | MEN1KMT2AALDH1A1GAAPOLB | |
| SCHEMBL4774938 | 0.79 | RECQL (0.49) | MEN1KMT2AALDH1A1GAAPOLB | |
| SCHEMBL4776728 | 0.77 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1GAAPOLB | |
| SCHEMBL5571358 | 0.76 | ALDH1A1 (0.54) | KMT2AALDH1A1GAAPOLBNPSR1 | |
| SCHEMBL4767920 | 0.76 | NR1H4 (0.50) | MEN1KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL4767621 | 0.76 | RECQL (0.49) | KMT2AALDH1A1GAAPOLBNPSR1 | |
| SCHEMBL4777302 | 0.76 | GAA (0.56) | MEN1KMT2AALDH1A1GAAPOLB | |
| SCHEMBL4777371 | 0.76 | ALDH1A1 (0.57) | KMT2AALDH1A1GAANPSR1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | claimed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |