Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.59 |
| ▸ | DRD4 | P21917 | 13/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567872 | 1.00 | DRD2 (0.59) | DRD2DRD4ALDH1A1POLBMEN1 | |
| SCHEMBL4777708 | 0.81 | MEN1 (0.49) | DRD2DRD4ALDH1A1POLBMEN1 | |
| SCHEMBL11463735 | 0.80 | DRD2 (0.75) | DRD2DRD4MEN1KMT2AMCHR1 | |
| SCHEMBL7694199 | 0.77 | DRD2 (0.85) | DRD2DRD4MCHR1HTR2A | |
| SCHEMBL7694198 | 0.77 | DRD2 (0.85) | DRD2DRD4MCHR1HTR2A | |
| SCHEMBL4768069 | 0.75 | GAA (0.64) | ALDH1A1POLBMEN1KMT2AGAA | |
| SCHEMBL11555632 | 0.75 | DRD2 (0.82) | DRD2DRD4MCHR1HTR2A | |
| SCHEMBL8707354 | 0.75 | DRD2 (1.00) | DRD2DRD4MCHR1HTR2A | |
| SCHEMBL8706290 | 0.75 | DRD2 (1.00) | DRD2DRD4MCHR1HTR2A | |
| SCHEMBL4777534 | 0.75 | USP30 (0.52) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | claimed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |