SCHEMBL4778077

SCHEMBL4778077

C=CC[SiH](CC=C)c1ccccc1C

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.36
ACHE P22303 2/20 0.36
ALDH1A1 P00352 4/20 0.31
MAOA P21397 1/20 0.31
MAOB P27338 1/20 0.31
TP53 P04637 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
MAPT P10636 1/20 0.30
HTT P42858 1/20 0.30
ESR1 P03372 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA7 P43166 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10975862 0.75 ALDH1A1 (0.40) TSHRALDH1A1
SCHEMBL16341010 0.73 CYP3A4 (0.33) ACHEALDH1A1MAOAMAOB
SCHEMBL28728735 0.73 TSHR (0.43) TSHRACHEALDH1A1MAOAMAOB
SCHEMBL1440023 0.71 TSHR (0.41) TSHRACHEALDH1A1CA1CA2
Fluoride SCHEMBL27912835 0.71 KMT2A (0.36) TSHRALDH1A1L3MBTL1MEN1KMT2A
SCHEMBL860549 0.69 CYP2C19 (0.36) TSHRALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL3690819 0.68 TSHR (0.38) TSHRACHEALDH1A1CA1CA2
SCHEMBL2274332 0.68 ACHE (0.38) TSHRACHEALDH1A1MEN1KMT2A
SCHEMBL6473749 0.68 TSHR (0.38) TSHRACHEALDH1A1CA1CA2
SCHEMBL8967622 0.67 TSHR (0.47) TSHRACHEALDH1A1SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963427-A1 FLUOROPOLYMER CURING CO-AGENT COMPOSITIONS 3M Innovative Properties Company (US) 2008-09-03 EP claimed
US-7388054-B2 Fluoropolymer curing co-agent compositions 3M INNOVATIVE PROPERTIES COMPANY (US) 2008-06-17 US claimed
WO-2007075261-A1 FLUOROPOLYMER CURING CO-AGENT COMPOSITIONS 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-07-05 WO claimed
US-20070149714-A1 FLUOROPOLYMER CURING CO-AGENT COMPOSITIONS 3M INNOVATIVE PROPERTIES COMPANY 2007-06-28 US claimed
EP-1963427-A1 FLUOROPOLYMER CURING CO-AGENT COMPOSITIONS 3M Innovative Properties Company (US) 2008-09-03 EP disclosed
US-7388054-B2 Fluoropolymer curing co-agent compositions 3M INNOVATIVE PROPERTIES COMPANY (US) 2008-06-17 US disclosed
WO-2007075261-A1 FLUOROPOLYMER CURING CO-AGENT COMPOSITIONS 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-07-05 WO disclosed
US-20070149714-A1 FLUOROPOLYMER CURING CO-AGENT COMPOSITIONS 3M INNOVATIVE PROPERTIES COMPANY 2007-06-28 US disclosed