SCHEMBL2274332

SCHEMBL2274332

COC[SiH](COC)c1ccccc1C

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.38
TSHR P16473 1/20 0.38
ESR1 P03372 1/20 0.35
MAPT P10636 2/20 0.33
ALOX15 P16050 1/20 0.33
MEN1 O00255 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
SCN4A P35499 6/20 0.32
KDM4E B2RXH2 2/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
HTT P42858 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8468947 0.79 TSHR (0.35) ACHETSHRESR1KDM4ECYP1A2
SCHEMBL30843822 0.76 SCN4A (0.37) ACHETSHRESR1SCN4ALMNA
SCHEMBL28728735 0.75 TSHR (0.43) ACHETSHRESR1MAPTMEN1
SCHEMBL64055 0.70 TSHR (0.43) ACHETSHRESR1MEN1RAB9A
SCHEMBL30492014 0.70 TSHR (0.43) ACHETSHRESR1MEN1RAB9A
SCHEMBL27595314 0.68 TSHR (0.41) ACHETSHRESR1MEN1RAB9A
SCHEMBL4778077 0.68 TSHR (0.36) ACHETSHRESR1MAPTMEN1
SCHEMBL1557214 0.68 TSHR (0.53) ACHETSHRESR1MAPTRAB9A
SCHEMBL3301718 0.67 TSHR (0.45) ACHETSHRESR1MAPTMEN1
SCHEMBL1049034 0.66 TSHR (0.50) ACHETSHRESR1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110196103-A1 PROPYLENE COPOLYMER, POLYPROPYLENE COMPOSITION AND USES THEREOF, TRANSITION METAL COMPOUND AND OLEFIN POLYMERIZATION CATALYST MITSUI CHEMICALS, INC. (US) 2011-08-11 US disclosed
US-7767313-B2 Polypropylene composite film comprising a metallocene-catalyzed propylene/1-butene random copolymer MITSUI CHEMICALS, INC. (JP) 2010-08-03 US disclosed
US-7737239-B2 Propylene copolymer, polypropylene composition and uses thereof, transition metal compound and olefin polymerization catalyst MITSUI CHEMICALS, INC. (JP) 2010-06-15 US disclosed
US-7728078-B2 Blend of a polypropylene and a elastomeric copolymer of 60-90 mol % propylene units and 10- 40 mol % of 1-butene units; sheets and films with excellent flexibility and impact resistance as well as sufficient heat resistance and low-temperature heat-sealability MITSUI CHEMICALS, INC. (JP) 2010-06-01 US disclosed
US-7678934-B2 Propylene copolymer, polypropylene composition and uses thereof, transition metal compound and olefin polymerization catalyst MITSUI CHEMICALS, INC. (JP) 2010-03-16 US disclosed
EP-1647575-B1 POLYPROPYLENE RESIN COMPOSITION PRIME POLYMER CO LTD (JP) 2009-07-29 EP disclosed
EP-1270647-B1 BRANCHED POLYOLEFIN, PROCESS FOR PRODUCING THE SAME, AND THERMOPLASTIC RESIN COMPOSITION CONTAINING BRANCHED POLYOLEFIN MITSUI CHEMICALS INC (JP) 2009-07-01 EP disclosed
US-20090043050-A1 PROPYLENE COPOLYMER, POLYPROPYLENE COMPOSITION AND USES THEREOF, TRANSITION METAL COMPOUND AND OLEFIN POLYMERIZATION CATALYST IKENAGA SHIGENOBU 2009-02-12 US disclosed
US-7488789-B2 Propylene copolymer, polypropylene composition, and uses thereof, transition metal compounds and catalyst for olefin polymerization MITSUI CHEMICALS, INC. (JP) 2009-02-10 US disclosed
US-20080312461-A1 PROPYLENE COPOLYMER, POLYPROPYLENE COMPOSITION AND USES THEREOF, TRANSITION METAL COMPOUND AND OLEFIN POLYMERIZATION CATALYST IKENAGA SHIGENOBU 2008-12-18 US disclosed
US-5595827-A BLEND WITH POLYTERPENE AND/OR PETROLEUM RESIN, MULTILAYER FILM FOR PACKAGING, WATER VAPOR BARRIER MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1997-01-21 US disclosed
EP-0634455-B1 Polypropylene resin composition and the use of the same MITSUI PETROCHEMICAL IND (JP) 1997-01-08 EP disclosed
US-5579913-A PACKAGING; WATERPROOFING, TRANSPARENT, HIGH MODULUS MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1996-12-03 US disclosed
EP-0683175-A2 Solid titanium catalyst component for olefin polymerization, process for preparation of the same, olefin polymerization catalyst and process for olefin polymerization MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-11-22 EP disclosed
EP-0669347-A1 Ethylene polymer, process for preparing the same, solid titanium catalyst component for ethylene polymerization and ethylene polymerization catalyst MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-08-30 EP disclosed
EP-0668296-A1 Ethylene polymer and process for preparing the same MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-08-23 EP disclosed
EP-0641807-A2 Olefin polymerization catalyst and process for preparing polypropylene and a propylene block copolymer MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-03-08 EP disclosed
EP-0634455-A1 Polypropylene resin composition and the use of the same MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-01-18 EP disclosed
EP-0585869-A1 Solid titanium catalyst component for olefin polymerization, process for preparing the same, catalyst for olefin polymerization and process for olefin polymerization MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-03-09 EP disclosed
EP-0452156-A2 Solid titanium catalyst component for olefin polymerization, olefin polymerization catalyst, prepolymerized polyolefin-containing catalyst and method of olefin polymerization MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1991-10-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080312461-A1 PROPYLENE COPOLYMER, POLYPROPYLENE COMPOSITION AND USES THEREOF, TRANSITION METAL COMPOUND AND OLEFIN POLYMERIZATION CATALYST PPIA, PPOX, PTGES2 ACHE 3365/4885TSHR 4231/4885ESR1 961/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.