Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779866 | 0.89 | DRD3 (0.49) | PGRDRD3LMNAPKMMAPK1 | |
| SCHEMBL4729823 | 0.89 | DRD3 (0.49) | PGRDRD3MAPTLMNAPKM | |
| SCHEMBL4728012 | 0.88 | CES1 (0.48) | DRD3MAPTLMNATDP1ALDH1A1 | |
| SCHEMBL4726510 | 0.87 | CNR2 (0.49) | DRD3MAPTLMNAPKMMAPK1 | |
| SCHEMBL4726498 | 0.86 | ALDH1A1 (0.44) | DRD3MAPTLMNATDP1PKM | |
| SCHEMBL4727043 | 0.85 | GFER (0.48) | DRD3MAPTLMNAALDH1A1 | |
| SCHEMBL4726646 | 0.84 | DRD3 (0.47) | DRD3CNR2 | |
| SCHEMBL4725464 | 0.83 | HDAC3 (0.49) | DRD3MAPTLMNAPKMHDAC3 | |
| SCHEMBL4725768 | 0.82 | MAPT (0.51) | DRD3MAPTLMNAPKMMAPK1 | |
| SCHEMBL4725454 | 0.82 | DRD3 (0.57) | PGRDRD3MAPTLMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | disclosed |