Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.41 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725768 | 0.90 | MAPT (0.51) | DRD3MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL4725454 | 0.89 | DRD3 (0.57) | DRD3MAPTDRD2KCNH2LMNA | |
| SCHEMBL4727610 | 0.89 | UCHL1 (0.51) | DRD3MAPTDRD2KCNH2LMNA | |
| SCHEMBL4729811 | 0.89 | ALDH1A1 (0.50) | DRD3MAPTLMNAHTTALDH1A1 | |
| SCHEMBL4726510 | 0.89 | CNR2 (0.49) | DRD3MAPTDRD2KCNH2LMNA | |
| SCHEMBL4778150 | 0.88 | PGR (0.50) | DRD3MAPTLMNAALDH1A1TDP1 | |
| SCHEMBL4726498 | 0.88 | ALDH1A1 (0.44) | DRD3MAPTDRD2KCNH2LMNA | |
| SCHEMBL4726548 | 0.87 | CRHBP (0.48) | DRD3MAPTDRD2KCNH2LMNA | |
| SCHEMBL4728036 | 0.87 | DRD3 (0.42) | DRD3MAPTDRD2KCNH2LMNA | |
| SCHEMBL4730511 | 0.87 | FFAR1 (0.44) | DRD3MAPTDRD2KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008026046-A1 | MORPHOLINE D3 DOPAMINE ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-03-06 | — | — | WO | disclosed |