Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | GLA | P06280 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | PDE2A | O00408 | 2/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL5315297 | 0.78 | AHR (0.68) | ALDH1A1HPGDGLAMAPTACHE | |
| Acridine SCHEMBL3045498 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HPGDGLAMAPTACHE | |
| Acridine SCHEMBL29352289 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HPGDGLAMAPTACHE | |
| Acridine SCHEMBL1772714 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HPGDGLAMAPTACHE | |
| Acridine SCHEMBL8339 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HPGDGLAMAPTACHE | |
| Acridine SCHEMBL4972293 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HPGDGLAMAPTACHE | |
| SCHEMBL22717041 | 0.73 | AXL (0.34) | AXLCDK8NUDT1PIK3CDPIK3CA | |
| SCHEMBL17897155 | 0.72 | APP (0.49) | AXLCDK8TRPA1CA1CA2 | |
| Acridine SCHEMBL30991444 | 0.72 | ALDH1A1 (0.52) | ALDH1A1HPGDGLAMAPTACHE | |
| Acridine SCHEMBL30991443 | 0.72 | ALDH1A1 (0.52) | ALDH1A1HPGDGLAMAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106999495-A | Combination of TLR inhibitor and bruton's tyrosine kinase inhibitor | 药品循环有限责任公司 | 2017-08-01 | — | — | CN | claimed |
| US-11731970-B1 | Pyrrolo[2,3-b]quinoline compounds as antibacterial agents | King Faisal University (SA) | 2023-08-22 | — | — | US | disclosed |
| US-11731970-B1 | Pyrrolo[2,3-b]quinoline compounds as antibacterial agents | King Faisal University (SA) | 2023-08-22 | — | — | US | disclosed |
| US-11731970-B1 | Pyrrolo[2,3-b]quinoline compounds as antibacterial agents | King Faisal University (SA) | 2023-08-22 | — | — | US | disclosed |
| CN-106999495-A | Combination of TLR inhibitor and bruton's tyrosine kinase inhibitor | 药品循环有限责任公司 | 2017-08-01 | — | — | CN | disclosed |
| WO-2008014249-A2 | IMPROVED PREPARATIONS OF 2 -SUBSTITUTED PYRROLO [2, 3-B] PYRAZINE ( 4, 7 -DIAZAINDOLE ) COMPOUNDS | SANOFI-AVENTIS (FR) | 2008-01-31 | — | — | WO | disclosed |
| US-6815442-B2 | A PHENOXY-ALKYL-QUINOXALINONE DERIVATIVES FOR INHIBITING DRUG TRANSPORT PROTEINS THAT EFFLUX THERAPEUTIC AGENTS FROM CELLS; SYNERGISTIC | THE PENN STATE RESEARCH FOUNDATION | 2004-11-09 | — | — | US | disclosed |
| US-6693112-B2 | FOR INHIBITING DRUG TRANSPORT FROM TARGET CELLS OR TISSUES IN AN ANIMAL UNDERGOING CHEMOTHERAPY; FOR PREVENTING DRUG RESISTANCE | THE PENNSYLVANIA STATE UNIVERSITY | 2004-02-17 | — | — | US | disclosed |
| US-20030203910-A1 | Novel compounds for enhancing chemotherapy | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-10-30 | — | — | US | disclosed |
| US-20030105122-A1 | Compounds for enhancing chemotherapy | THE PENN STATE RESEARCH FOUNDATION. | 2003-06-05 | — | — | US | disclosed |
| US-6537993-B2 | Compounds for enhancing chemotherapy | PENN STATE RESEARCH FOUNDATION | 2003-03-25 | — | — | US | disclosed |
| EP-1272479-A2 | NOVEL COMPOUNDS FOR ENHANCING CHEMOTHERAPY | THE PENN STATE RESEARCH FOUNDATION (US) | 2003-01-08 | — | — | EP | disclosed |
| US-20020013322-A1 | Novel compounds for enhancing chemotherapy | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-01-31 | — | — | US | disclosed |
| WO-2001074790-A2 | NOVEL COMPOUNDS FOR ENHANCING CHEMOTHERAPY | THE PENN STATE RESEARCH FOUNDATION (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-0585913-B1 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5482967-A | LOWERING CHOLESTEROL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-01-09 | — | — | US | disclosed |
| CN-1090274-A | Condensed heterocyclic compounds and its preparation method and application | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-08-03 | — | — | CN | disclosed |
| EP-0585913-A2 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203910-A1 | Novel compounds for enhancing chemotherapy | ABCB1, ABCB11, ABCC1 | ALDH1A1 2236/4885HPGD 2330/4885GLA 4797/4885 |
| US-11731970-B1 | Pyrrolo[2,3-b]quinoline compounds as antibacterial agents | POLB, TOP2A, POLR2B | ALDH1A1 3817/4885HPGD 966/4885GLA 753/4885 |
| US-20020013322-A1 | Novel compounds for enhancing chemotherapy | ABCB1, ABCB11, ABCC1 | ALDH1A1 2236/4885HPGD 2330/4885GLA 4797/4885 |
| US-20030105122-A1 | Compounds for enhancing chemotherapy | NQO2, MCL1, ABCB1 | ALDH1A1 555/4885HPGD 682/4885GLA 3873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.