Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5610695 | 0.89 | MEN1 (0.44) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL5495434 | 0.84 | ALDH1A1 (0.38) | MEN1KMT2AALDH1A1TSHRNR3C1 | |
| SCHEMBL578043 | 0.84 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL4781858 | 0.81 | FDPS (0.38) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL7151009 | 0.81 | AOC3 (0.49) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL5241041 | 0.80 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL2730801 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL5290521 | 0.79 | MEN1 (0.53) | MEN1KMT2AALDH1A1TSHRLMNA | |
| Formaldehyde SCHEMBL5244081 | 0.78 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1TSHRLMNA | |
| SCHEMBL24541830 | 0.77 | CA1 (0.40) | MEN1KMT2AALDH1A1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016811-A2 | AMINOPIPERIDINES AND REALTED COMPOUNDS | NEUROGEN CORPORATION (US) | 2008-02-07 | — | — | WO | disclosed |
| EP-1756107-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2006009789-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-01-26 | — | — | WO | disclosed |
| WO-2005110982-A2 | SUBSTITUTED 1-BENZYL-4-SUBSTITUTED PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |