Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.43 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14260024 | 0.86 | APP (0.56) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4728088 | 0.86 | RAB9A (0.61) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4886789 | 0.81 | ALDH1A3 (0.43) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL15177306 | 0.77 | APP (0.73) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1691247 | 0.76 | NPC1 (0.80) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4729831 | 0.74 | APP (0.72) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL24320031 | 0.73 | NPC1 (0.74) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL13217820 | 0.72 | RAB9A (0.81) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL14076016 | 0.72 | APP (0.66) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2899627 | 0.71 | ALDH1A3 (0.70) | APPNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |